Vitamin D3 K2-MK7

Dosage and preparation

Take 3 drops a day, preferably in the morning. You can place them directly on your tongue or add them to a dish or drink of your choice.

Instructions for use

NUTRIPURE’s vitamin D3 K2 is recommended:

All year round for people with limited exposure to sunlight.

From October to March for people who are exposed to sunlight during the summer.

From October to March for children, in accordance with the recommendations of the French Paediatric Society (2 drops from the age of 4 and 3 drops from the age of 15)

It is best to take it

In the morning

Vitamin D and vitamin K play an important role in bone health.

Vitamin D is naturally synthesised by the skin during exposure to sunlight: winter or working in an office can lead to a deficiency in our vitamin D synthesis, which is essential for the immune and muscular systems.

Vitamin K plays an essential role in blood clotting. The form naturally produced by bacteria in the digestive tract is K2. Its benefits are considerable. It plays a particularly important role in cardiovascular health.

The vitamin D + K2 MK7 complex is therefore the ideal supplement for combating the effects of ageing on bone health, cardiovascular health and ensuring a healthy immune response, especially in winter.

The synergy of vitamins D3 and K2 for your health

Vitamin D3 and vitamin K2 support the proper absorption and utilisation of calcium and phosphorus, which helps maintain strong bones.

Vitamin K2 supports normal blood clotting.

Vitamin D3 contributes to the maintenance of normal muscle function and the normal functioning of the immune system.

Vitamin D3 helps maintain teeth in a normal condition.

The benefits of Nutripure’s Vitamin D3 K2

• 100% of customers are satisfied or very satisfied with the product*
• 100% felt an improvement in their health*
• 86% felt an improvement in their immune system*
• 58% felt an improvement in their dental health*
• On average, it takes 28 DAYS to feel the benefits of Vitamin D3 K2*

28 DAYS on average to feel the benefits of Vitamin D3 K2*

* Satisfaction survey carried out on a panel of randomly selected customers

The benefits of vitamin D, the ‘sunshine vitamin’

As vitamin D is fat-soluble, our bodies can store excess amounts of it. However, vitamin D deficiency, particularly during winter, affects over 80% of the population.

Vitamin D is essential for muscle function and bone strength.

The body is able to absorb it through exposure to sunlight, but our lifestyle often results in insufficient exposure to sunlight—specifically UVB radiation—and the body often struggles to synthesise enough vitamin D.

This vitamin plays a key role for athletes, as vitamin D contributes to muscle function.

Vitamin K2 for good bone health

Vitamin D3 and vitamin K2 enable the body to properly absorb and utilise calcium.

The first benefit is maintaining bone health by playing a role in bone mineralisation.

The second benefit of improved calcium utilisation is the reduction of vascular calcification (through the activation of osteocalcin and matrix protein).

This action is complemented by the beneficial effect of vitamin K on blood clotting.

A deficiency in our daily lives

A large-scale study by the Robert Koch Institute (5) involving 6,995 participants aged between 18 and 79 in Germany shows that over 55% of those studied are deficient in vitamin D.

The sun is the main source of vitamin D synthesis: it accounts for between 80% and 90% of vitamin D intake if one spends time outdoors regularly. People with insufficient exposure are prone to deficiency.

Food is a minor source of vitamin D (between 10% and 20%) because foods rich in vitamin D are rarely consumed in our diet (mushrooms, eggs, offal, oily fish).

If you want to know where to find it naturally, discover foods containing vitamin D in our comprehensive guide.

Whether as part of the ageing process or as part of sustained physical activity, vitamin D supplementation will have a beneficial effect on the health of your bones, teeth and immune system.

Vitamin D3

Overview

Vitamin D3, or cholecalciferol, is a hormone that occurs naturally in the body. The body obtains it from food, but also through endogenous synthesis triggered by sunlight. Most of the vitamin D3 in our bodies comes from this synthesis (between 80 and 90 per cent). (1) Known as the ‘sunshine vitamin’, it is produced in the skin upon exposure to UV-B rays.

This biosynthesis (Figure 1) begins primarily in the skin, where UV-B rays react with 7-dehydrocholesterol (cutaneous provitamin D) to produce provitamin D3. This provitamin D3 is subsequently isomerised into cholecalciferol (or vitamin D3). Vitamin D3 is therefore not active and is converted in the liver and then in the kidneys into its biologically active form, 1,25-dihydroxyvitamin D3 or 1,25 (OH)₂ D₃. Cytochromes P (CYP) are responsible for this activation.

In the liver, 25-hydroxyvitamin D₃ or 25(OH)D₃ is synthesised from vitamin D₃ via the action of CYP27A1, CYP2R1, CYP2J3 or CYP3A4. In target tissues, the 1α-hydroxylase CYP27B1 synthesises the biologically active form, 1,25-dihydroxyvitamin D3 or 1,25(OH)₂D3.

Once synthesised, active vitamin D3 diffuses throughout the body and acts on its target organs, such as the intestine, bones, kidneys and parathyroid glands. Its catabolism (primarily in the kidney) is initiated by the 24-hydroxylase CYP24A1. (2)

Whilst a large proportion of vitamin D3 is endogenous, the remainder is exogenous. In other words, it comes from foods of animal origin (unlike vitamin D2, which is obtained through a plant-based diet). In general, foods rich in vitamin D3 include:

• Oily fish (salmon, herring, sardines, mackerel, etc.)
• Cod liver oil
• Offal
• Eggs
• Milk and soya drinks
• Butter and certain cheeses

According to ANSES recommendations, the daily requirement for vitamin D3 in adults is 15 µg or 600 IU. This requirement increases to 20 µg (800 IU) in people over the age of 70. (3)

Physiological roles

Vitamin D3 performs various functions in the body and has been extensively studied by the scientific community. We will analyse the following two statements regarding vitamin D3 supplementation using clinical studies and scientific articles:

• Vitamin D3 helps to maintain the immune system.
• Vitamin D3 helps to maintain normal muscle function.

Supporting the immune system

Over the last 20 years, a growing body of scientific research has revealed a link between vitamin D deficiency and an increased risk of various infectious diseases, as well as a poorer prognosis for patients with vitamin D deficiency when they contract infections. (4)

The primary function of vitamin D is to regulate and strengthen the immune system. It activates and contributes to the formation of the immune system, but its main action is to regulate it. It is therefore an essential and indispensable element for the body’s resistance. It regulates not only the innate immune system but also the adaptive immune system. In the innate immune system, vitamin D promotes the production of antibodies such as defensins and cathelicidins, enhancing their antibacterial and antiviral action. Furthermore, vitamin D3 stimulates the breakdown of pathogens by macrophages.

As for the adaptive immune system, it exerts an anti-inflammatory effect that reduces the growth of TH2 cells and reinforces the regulatory T-cell compartments. In this way, it helps prevent an excessive immune response and ensures that the body can combat pathogens through the formation of antibodies.

Vitamin D is not only essential in the face of acute conditions, but also helps prevent the onset of chronic inflammatory and autoimmune diseases. It therefore performs multiple functions, particularly in the distribution of antibodies within bodily fluids. It also regulates the immune response to prevent chronic inflammation and moderates the immune system’s reactivity. (5)

A study conducted by Adrian N. Martineau et al. in 2011 highlighted the role of vitamin D3 in immunity. (6) This was a multicentre, randomised controlled trial of vitamin D as an adjuvant treatment in adults with pulmonary tuberculosis.

A total of 126 participants were divided into two groups to receive 2.5 mg of vitamin D3 or a placebo at baseline and at 2, 4 and 6 weeks after starting standard anti-tuberculosis treatment. The primary endpoint of the trial was the time elapsed from the start of antimicrobial treatment to sputum culture conversion.

The median time to sputum culture conversion was 36.0 days in the vitamin D3 group and 43.5 days in the placebo group. Therefore, the administration of four 2.5 mg doses of vitamin D3 increased serum 25-hydroxyvitamin D concentrations in patients receiving intensive treatment for pulmonary tuberculosis and reduced the time to sputum culture conversion in the participants.

Maintenance of normal muscle function

According to various studies and clinical trials, there appears to be a link between muscle strength and vitamin D. In fact, vitamin D3 influences physical performance. A deficiency can, for example, increase the risk of falls in older people. It is also important to note that, according to epidemiological surveys and studies, a decline in muscle mass and capacity, as well as a lack of strength in older people, is consistently associated with vitamin D deficiency. (5)

In 1999, Heike A. et al. demonstrated the relationship between vitamin D and muscle strength in older people. (6) The study involved 319 patients selected at random from participants in an ongoing interdisciplinary study on ageing.